![]() ![]() Induces oxidative stress in the brain, resulting in lipid peroxidation, protein oxidation, and cognitive impairment. Plaques with entrapped metal ions produce free radicals, such as ROS and reactive nitrogen species (RNS). Plaques and modulate the aggregation process. Moreover, several studies have reported that metal ions (e.g., zinc, iron, and copper) that bind A ? The brain, which consumes large amounts of oxygen, may be notably sensitive to oxidative damage. Oxidative stress is caused by the disequilibrium of the redox reaction and generates excessive reactive oxygen species (ROS) in the body. Peptide, plays a critical role in the development of AD by inducing oxidative stress, neurotoxicity, and inflammatory response. The A ? 25-35įragment used in the present study, a core toxic fragment cleaved from the full-length A ? Therefore, therapeutic approaches targeting A ? Plaques in later stages are established, so they are observed in the AD brain for decades before the onset of memory/behavior/cognitive symptoms. (i.e., oligomers and senile plaques) are highly neurotoxic and form A ?ĭeposit/fibrils, which can contribute to AD development. ![]() Previous studies have demonstrated that the accumulation and aggregation of A ? secretase), which leads to memory loss and cognitive decline by the formation of senile plaques. Is derived from amyloid precursor protein (APP) through the proteolytic cleavage of a family of enzymes ( ? Therefore, CJM may be useful for the treatment of AD and may be a potential material for functional foods.Īlzheimer's disease (AD) is a neurodegenerative disease, and its main feature is the excessive accumulation of amyloid beta (A ? The present study indicates that ECJM improves cognitive impairment by inhibiting oxidative stress in A? -induced mice. Additionally, ECJM-administered mice experienced inhibited lipid peroxidation and nitric oxide production in a dose-dependent manner. In the Morris water maze test, ECJM-administered mice showed greater learning and memory abilities than A? -induced control mice. In the T-maze and novel object recognition test, ECJM provided higher spatial memory and object recognition compared to A? treatment alone. This study focused on the protective effect of the ethyl acetate fraction from CJM (ECJM) on A? -induced control mice. maackii (CJM) is widely used as an herbal medicine and has antibacterial and anti-inflammatory properties. Abnormal production and degradation of amyloid beta (A? ) in the brain lead to oxidative stress and cognitive impairment in Alzheimer's disease (AD). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |